Reduced Orbitofrontal-Striatal Activity on a Reversal Learning Task in Obsessive-Compulsive Disorder
Archives of General Psychiatry2006Vol. 63(11), pp. 1225–1225
Citations Over TimeTop 1% of 2006 papers
Peter L. Remijnse, Marjan M. A. Nielen, Anton J.L.M. van Balkom, Daniëlle C. Cath, Patricia van Oppen, H.B.M. Uylings, Dick J. Veltman
Abstract
These data show behavioral impairments accompanied by aberrant OFC-striatal and dorsal prefrontal activity in OCD on a reversal learning task that addresses this circuit's function. These findings not only confirm previous reports of dorsal prefrontal dysfunction in OCD but also provide evidence for the involvement of the OFC-striatal loop in the pathophysiology of OCD.
Related Papers
- → A functional difference in information processing between orbitofrontal cortex and ventral striatum during decision-making behaviour(2014)61 cited
- → Parcellation of the striatal complex into dorsal and ventral districts(2020)35 cited
- → The ventral striatum(2009)30 cited
- → Functional connectivity between anterior cingulate cortex and orbitofrontal cortex during value-based decision making(2017)27 cited
- → Repression of Dlx1/2 Signaling by Nolz-1/Znf503 is Essential for Parcellation of the Striatal Complex into Dorsal and Ventral Striatum(2018)