Effect of Intensive Compared With Moderate Lipid-Lowering Therapy on Progression of Coronary Atherosclerosis
JAMA2004Vol. 291(9), pp. 1071–1071
Citations Over TimeTop 1% of 2004 papers
Steven E. Nissen, E. Murat Tuzcu, Paul Schoenhagen, B. Greg Brown, Peter Ganz, Robert A. Vogel, Tim Crowe, Gail Howard, Christopher B. Cooper, Bruce R. Brodie, Cindy L. Grines, Anthony N. DeMaria, for the REVERSAL Investigators
Abstract
For patients with coronary heart disease, intensive lipid-lowering treatment with atorvastatin reduced progression of coronary atherosclerosis compared with pravastatin. Compared with baseline values, patients treated with atorvastatin had no change in atheroma burden, whereas patients treated with pravastatin showed progression of coronary atherosclerosis. These differences may be related to the greater reduction in atherogenic lipoproteins and C- reactive protein in patients treated with atorvastatin.
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