Mapping the Heterogeneous Phenotype of Schizophrenia and Bipolar Disorder Using Normative Models
JAMA Psychiatry2018Vol. 75(11), pp. 1146–1146
Citations Over TimeTop 1% of 2018 papers
Thomas Wolfers, Nhat Trung Doan, Tobias Kaufmann, Dag Alnæs, Torgeir Moberget, Ingrid Agartz, Jan K. Buitelaar, Torill Ueland, Ingrid Melle, Barbara Franke, Ole A. Andreassen, Christian F. Beckmann, Lars T. Westlye, André F. Marquand
Abstract
This study found that group-level differences disguised biological heterogeneity and interindividual differences among patients with the same diagnosis. This finding suggests that the idea of the average patient is a noninformative construct in psychiatry that falls apart when mapping abnormalities at the level of the individual patient. This study presents a workable route toward precision medicine in psychiatry.
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