Platelet mitochondrial membrane potential in Parkinson's disease
Annals of Clinical and Translational Neurology2014Vol. 2(1), pp. 67–73
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Paul Antony, Olga Boyd, Christophe Trefois, Wim Ammerlaan, Marek Ostaszewski, Aidos Baumuratov, Laura Longhino, Laurent Antunes, Werner J.H. Koopman, Rudi Balling, Nico J. Diederich
Abstract
While the reported protonophore challenge assay is a valid marker of overall mitochondrial function in live platelets, intact mitochondrial membrane potential in platelets derived from IPD patients suggests that presumed mitochondrial enzymatic deficiencies are compensable in this cell type. In consequence, mitochondrial membrane potential in platelets cannot be used as a diagnostic biomarker for nonstratified IPD but should be further explored in potential Parkinson's disease subtypes and tissues with higher energy demands.
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