SelectiveROCK2 inhibition in focal cerebral ischemia
Annals of Clinical and Translational Neurology2013Vol. 1(1), pp. 2–14
Citations Over TimeTop 10% of 2013 papers
Jeong Hyun Lee, Yi Zheng, Daniel von Bornstädt, Ying Wei, Aygul Balcioglu, Ali Daneshmand, Nilufer Yalcin, Esther S. Yu, Fanny Hérisson, Yahya B Atalay, Maya Hwewon Kim, Yong‐Joo Ahn, Mustafa Balkaya, Paul M. Sweetnam, Olivier Schueller, Masha V. Poyurovsky, Hyung‐Hwan Kim, Eng H. Lo, Karen L. Furie, Cenk Ayata
Abstract
Altogether, these data show that KD025 is efficacious and safe in acute focal cerebral ischemia in mice, implicating ROCK2 as the relevant isoform in acute ischemic stroke. Data suggest that selective ROCK2 inhibition has a favorable safety profile to facilitate clinical translation.
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