Baseline results of the NeuroNEXT spinal muscular atrophy infant biomarker study
Annals of Clinical and Translational Neurology2016Vol. 3(2), pp. 132–145
Citations Over TimeTop 10% of 2016 papers
Stephen J. Kolb, Christopher S. Coffey, Jon Yankey, Kristin J. Krosschell, W. David Arnold, Seward B. Rutkove, Kathryn J. Swoboda, Sandra P. Reyna, Ai Sakonju, Basil T. Darras, Richard Shell, Nancy L. Kuntz, Diana Castro, Susan T. Iannaccone, Julie Parsons, Anne M. Connolly, Claudia A. Chiriboga, Craig M. McDonald, W. Bryan Burnette, Klaus Werner, Mathula Thangarajh, Perry B. Shieh, Erika Finanger, Merit Cudkowicz, Michelle McGovern, D. Elizabeth McNeil, Richard S. Finkel, Edward M. Kaye, Allison Kingsley, Samantha Renusch, Vicki L. McGovern, Xueqian Wang, Phillip G. Zaworski, Thomas W. Prior, Arthur H.M. Burghes, Amy Bartlett, John T. Kissel
Abstract
By the time infants were recruited and presented for the baseline visit, SMA infants had reduced motor function compared to controls. Ulnar CMAP, EIM, blood SMN mRNA levels, and serum protein analytes were able to distinguish between cohorts at the enrollment visit.
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