Model‐based lamotrigine clearance changes during pregnancy: clinical implication
Annals of Clinical and Translational Neurology2014Vol. 1(2), pp. 99–106
Citations Over TimeTop 10% of 2014 papers
Akshanth R. Polepally, Page B. Pennell, Richard C. Brundage, Zachary N. Stowe, D. Jeffrey Newport, Adele C. Viguera, James Ritchie, Angela K. Birnbaum
Abstract
The majority of women had a substantial increase in CL/F from 2.16 to 6.88 L/h by the end of pregnancy, whereas 23% of women had a minimal increase. An increase in CL/F may correspond to decreases in LTG blood concentrations necessitating the need for more frequent dosage adjustments and closer monitoring in some pregnant women with epilepsy. Postpartum doses should be tapered to preconception dose ranges within 3 weeks of delivery.
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