11C‐PK11195 PET–based molecular study of microglia activation in SOD1 amyotrophic lateral sclerosis
Annals of Clinical and Translational Neurology2020Vol. 7(9), pp. 1513–1523
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Giacomo Tondo, Leonardo Iaccarino, Chiara Cerami, G Vanoli, Luca Presotto, Valeria Masiello, Angela Coliva, Fabrizio Salvi, Ilaria Bartolomei, Lorena Mosca, Christian Lunetta, Daniela Perani
Abstract
In vivo neuroinflammation occurred in all SOD1 mutated cases since the presymptomatic stages, as shown by a significant cortical and subcortical microglia activation. The involvement of sensorimotor cortex became evident at the symptomatic disease stage. Although our data indicate the role of in vivo PET imaging for assessing resident microglia in the investigation of SOD1-ALS pathophysiology, further studies are needed to clarify the temporal and spatial dynamics of microglia activation and its relationship with neurodegeneration.
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