Improved stratification of ALS clinical trials using predicted survival
Annals of Clinical and Translational Neurology2018Vol. 5(4), pp. 474–485
Citations Over TimeTop 11% of 2018 papers
James D. Berry, Albert A. Taylor, Danielle Beaulieu, Lisa Meng, Amy Bian, Jinsy Andrews, Mike Keymer, David L. Ennist, Bernard Ravina
Abstract
Stratifying randomization based on predicted survival using a machine learning algorithm is more likely to maintain balance between trial arms than traditional stratification methods. The methodology described here can translate to smaller, more efficient clinical trials for numerous neurological diseases.