Aging related cognitive changes associated with Alzheimer's disease in Down syndrome
Annals of Clinical and Translational Neurology2018Vol. 5(6), pp. 741–751
Citations Over TimeTop 10% of 2018 papers
Nicholas C. Firth, Carla M. Startin, Rosalyn Hithersay, Sarah Hamburg, P. A. Wijeratne, Kin Y. Mok, John Hardy, Daniel C. Alexander, André Strydom
Abstract
Our results identify tests of memory and sustained attention may be particularly useful measures to track decline in the preclinical/prodromal stages of AD in DS whereas informant-measures may be useful in later stages (i.e. during conversion into dementia, or postdiagnosis). These results have implications for the selection of outcome measures of treatment trials to delay or prevent cognitive decline due to AD in DS. As clinical diagnoses are generally made late into AD progression, early assessment is essential.
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