Temperature‐Controlled Assembly and Release from Polymer Vesicles of Poly(ethylene oxide)‐block‐ poly(N‐isopropylacrylamide)
Advanced Materials2006Vol. 18(21), pp. 2905–2909
Citations Over TimeTop 1% of 2006 papers
Abstract
Narrow-dispersity thermoresponsive block copolymers of poly(ethylene oxide)-block-poly(N-isopropylacrylamide) self-assemble into vesicles at temperatures above 32 °C. The vesicles integrate a hydrophobic fluorescent dye into their membranes and encapsulate the hydrophilic anticancer drug doxorubicin. Temperature-controlled release of the dye through disintegration of the vesicles takes place at temperatures below 32 °C, as shown in the figure.
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