Protein Detecting Arrays Based on Cationic Polythiophene–DNA‐Aptamer Complexes
Advanced Materials2006Vol. 18(20), pp. 2703–2707
Citations Over TimeTop 10% of 2006 papers
M. Béra Abérem, Ahmed Najari, H.‐A. Ho, Jean-François Gravel, Philippe Nobert, Denis Boudreau, Mario Leclerc
Abstract
By combining an appropriate DNA aptamer with a cationic polythiophene optical transducer, human thrombin can be specifically detected on microarrays in the attomole range in less than one hour without any tagging of the target. The system can be modified and utilized as a probe for the detection of various proteins or other biomolecules. This work opens new interesting possibilities for simple and rapid multiparametric analysis in genomics and proteomics.
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