Thermo and pH Dual‐Responsive Nanoparticles for Anti‐Cancer Drug Delivery
Citations Over TimeTop 10% of 2007 papers
Abstract
Thermo and pH dual-responsive nanoparticles encapsulating an anti-cancer drug (paclitaxel) were assembled from a diblock copolymer comprised of a hydrophilic poly(N-isopropylacrylamide-co-acrylic acid) block and a hydrophobic polycaprolactone block. These nanoparticles aggregated at body temperature under a slightly acidic pH of 6.9 (see figure), and a faster drug release was found to be associated with higher temperature and lower pH, both of which are advantageous for tumor-targeted anti-caner drug delivery. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2007/c1817_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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