Traumatic Brain Injury Imaging in the Second Near‐Infrared Window with a Molecular Fluorophore
Advanced Materials2016Vol. 28(32), pp. 6872–6879
Citations Over TimeTop 1% of 2016 papers
Xiaodong Zhang, Huasen Wang, Alexander L. Antaris, Lulin Li, Shuo Diao, Rui Ma, Andy Nguyen, Guosong Hong, Zhuoran Ma, Joy Wang, Shoujun Zhu, Joseph M. Castellano, Tony Wyss‐Coray, Yongye Liang, Jian Luo, Hongjie Dai
Abstract
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. A bright, renal-excreted, and biocompatible near-infrared II fluorophore for in vivo imaging of TBI is designed. A transient hypoperfusion in the injured cerebral region, followed by fluorophore leakage, is observed. NIR-II fluorophores can provide noninvasive assessment of TBI.
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