Biomimetic Immuno‐Magnetosomes for High‐Performance Enrichment of Circulating Tumor Cells
Advanced Materials2016Vol. 28(36), pp. 7929–7935
Citations Over TimeTop 10% of 2016 papers
Ke Xiong, Wei Wei, Yongjie Jin, Shumin Wang, Dongxu Zhao, Shuang Wang, Xiaoyong Gao, Chen-Meng Qiao, Hua Yue, Guanghui Ma, Hai‐Yan Xie
Abstract
A novel biomimetic immuno-magnetosome (IMS) is developed by coating a leukocyte membrane (decorated with anti-epithelial cell-adhesion molecule antibody) on a magnetic nanocluster. In addition to the good stability and magnetic controllability, the IMS also exhibits satisfactory binding avidity to circulating tumor cells but stealth property to leukocytes. As a result, rare tumor cells can be effectively enriched with undetectable leukocyte background.
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