Catalytic Isonitrile Insertions and Condensations Initiated by RNC–X Complexation
Advanced Synthesis & Catalysis2014Vol. 356(10), pp. 2135–2196
Citations Over TimeTop 10% of 2014 papers
Suravi Chakrabarty, Shruti Choudhary, Arpit Doshi, Fa‐Qiang Liu, Rishabh Mohan, Manasa Ravindra, Dhruv Shah, X.-M. Yang, Fraser F. Fleming
Abstract
Isonitriles are delicately poised chemical entities capable of being coaxed to react as nucleophiles or electrophiles. Directing this tunable reactivity with metal and non-metal catalysts provides rapid access to a large array of complex nitrogenous structures ideally functionalized for medicinal applications. Isonitrile insertion into transition metal complexes has featured in numerous synthetic and mechanistic studies, leading to rapid deployment of isonitriles in numerous catalytic processes, including multicomponent reactions (MCR). Covering the literature from 1990-2014, the present review collates reaction types to highlight reactivity trends and allow catalyst comparison.
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