Deep Tumor‐Penetrated Nanocages Improve Accessibility to Cancer Stem Cells for Photothermal‐Chemotherapy of Breast Cancer Metastasis

Citations Over TimeTop 10% of 2018 papers

Abstract

Abstract Cancer stem cells (CSCs) are proposed to account for the initiation of cancer metastasis, but their accessibility remains a great challenge. This study reports deep tumor‐penetrated biomimetic nanocages to augment the accessibility to CSCs fractions in tumor for anti‐metastasis therapy. The nanocages can load photothermal agent of 1,1‐dioctadecyl‐3,3,3,3‐tetramethylindotricarbocyanine iodide (DBN) and chemotherapeutic epirubicin (EBN) to eradicate CSCs for photothermal‐chemotherapy of breast cancer metastasis. In metastatic 4T1‐indcued tumor model, both DBN and EBN can efficiently accumulate in tumor sites and feasibly permeate throughout the tumor mass. These biomimetic nanosystems can be preferentially internalized by cancer cells and effectively accessed to CSCs fractions in tumor. The DBN+laser/EBN treatment produces considerable depression of primary tumor growth, drastically eradicates around 80% of CSCs fractions in primary tumor, and results in 95.2% inhibition of lung metastasis. Thus, the biomimetic nanocages can be a promising delivery nanovehicle with preferential CSCs‐accessibility for effective anti‐metastasis therapy.

Related Papers

• → Self-Assembly of Responsive Multilayered DNA Nanocages(2015)101 cited
• → Chemically coupled NiCoS/C nanocages as efficient electrocatalysts for nitrogen reduction reactions(2019)67 cited
• → Hollow Boron Nitride (BN) Nanocages and BN‐Nanocage‐Encapsulated Nanocrystals(2004)59 cited
• → Thin-walled graphitic nanocages with nitrogen-doping as superior performance anodes for lithium-ion batteries(2016)20 cited
• → Gold Nanocages: A Multifunctional Platform for Molecular Optical Imaging and Photothermal Treatment(2011)1 cited