Tyrosine‐Rich Peptides as a Platform for Assembly and Material Synthesis

Citations Over TimeTop 10% of 2018 papers

Abstract

The self-assembly of biomolecules can provide a new approach for the design of functional systems with a diverse range of hierarchical nanoarchitectures and atomically defined structures. In this regard, peptides, particularly short peptides, are attractive building blocks because of their ease of establishing structure-property relationships, their productive synthesis, and the possibility of their hybridization with other motifs. Several assembling peptides, such as ionic-complementary peptides, cyclic peptides, peptide amphiphiles, the Fmoc-peptide, and aromatic dipeptides, are widely studied. Recently, studies on material synthesis and the application of tyrosine-rich short peptide-based systems have demonstrated that tyrosine units serve as not only excellent assembly motifs but also multifunctional templates. Tyrosine has a phenolic functional group that contributes to π-π interactions for conformation control and efficient charge transport by proton-coupled electron-transfer reactions in natural systems. Here, the critical roles of the tyrosine motif with respect to its electrochemical, chemical, and structural properties are discussed and recent discoveries and advances made in tyrosine-rich short peptide systems from self-assembled structures to peptide/inorganic hybrid materials are highlighted. A brief account of the opportunities in design optimization and the applications of tyrosine peptide-based biomimetic materials is included.

Related Papers

• → Template routes to interlocked molecular structures and orderly molecular entanglements(2000)376 cited
• → Design of Sub-40nm FinFET Based Label Free Biosensor(2022)16 cited
• → A general approach for biomimetic mineralization of MOF particles using biomolecules(2020)48 cited
• → Biomolecule-sensitive Hydrogels(2013)5 cited
• THE PHOTOCHEMICAL METHODS OF IMMOBILIZATION BIOMOLECULES ON POLYMER MATERIALS(2001)