Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management
American Journal of Hematology2011Vol. 86(6), pp. 484–489
Citations Over TimeTop 10% of 2011 papers
Erfan Nur, Bart J. Biemond, Hans‐Martin Otten, Dees P. M. Brandjes, John‐John B. Schnog, the CURAMA Study Group
Abstract
Sickle cell disease (SCD) is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and vaso-occlusion leading to a reduced quality of life and life expectancy. Oxidative stress is an important feature of SCD and plays a significant role in the pathophysiology of hemolysis, vaso-occlusion and ensuing organ damage in sickle cell patients. Reactive oxygen species (ROS) and the (end-)products of their oxidative reactions are potential markers of disease severity and could be targets for antioxidant therapies. This review will summarize the role of ROS in SCD and their potential implication for SCD management.
Related Papers
- → Oxidative stress and mitochondrial dysfunction in glaucoma(2012)387 cited
- → Sex-related differences in oxidative stress and neurodegeneration(2017)106 cited
- → RETRACTED ARTICLE: The modulatory potential of herbal antioxidants against oxidative stress and heavy metal pollution: plants against environmental oxidative stress(2021)55 cited
- → Important Role of Oxidative Stress Biomarkers in Huntington’s Disease(2011)91 cited
- → Oxidative Stress in Relation to Aging and Exercise(2022)25 cited