Click to Release: Instantaneous Doxorubicin Elimination upon Tetrazine Ligation
Angewandte Chemie International Edition2013Vol. 52(52), pp. 14112–14116
Citations Over TimeTop 10% of 2013 papers
Abstract
Eliminated without a trace: The fastest click reaction, the highly selective inverse-electron-demand Diels-Alder reaction, has been modified to enable selective bioorthogonal release. Thus, the click reaction of a tetrazine with a drug-bound trans-cyclooctene caused the instantaneous release of the drug and CO2 (see scheme). One possible application is the chemically triggered release, and thereby activation, of a drug from a tumor-bound antibody-drug conjugate.
Related Papers
- → Light-activated tetrazines enable precision live-cell bioorthogonal chemistry(2022)130 cited
- → Development of a18F‐Labeled Tetrazine with Favorable Pharmacokinetics for Bioorthogonal PET Imaging(2014)124 cited
- → Overview of Syntheses and Molecular-Design Strategies for Tetrazine-Based Fluorogenic Probes(2021)49 cited
- → A tetrazine-fused aggregation induced emission luminogen for bioorthogonal fluorogenic bioprobe(2021)28 cited
- → Control of tetrazine bioorthogonal reactivity by naphthotube and phenyltetrazine host-guest pairs(2023)3 cited