Preparation of antibacterial poly(sulfobetaine methacrylate) grafted on poly(vinyl alcohol)‐formaldehyde sponges and their properties

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Abstract

ABSTRACT Conventional wound dressings cover wound surfaces and separate them from the outer environment. However, wound sites are readily infected by some bacteria during healing. To overcome these problems, a macroporous sample is designed through the grafting polymerization of hydrophilic sulfobetaine methacrylate (SBMA) on poly(vinyl alcohol)‐formaldehyde (PVF) sponges. The as‐prepared PVF sponges have a grafting percentage of 15–50%, an average pore size of 60–90 μm, and a high porosity of 90%. This series of PVF‐g‐PSBMA sponges can absorb deionized water and saline solution at approximately 16 g·g −1 within 2 min because of their hydrophilic surface and macroporous structure. The antibacterial potential of PVF‐g‐PSBMA sponges against Escherichia coli and Staphylococcus aureus is evaluated via a shake flask test. As the grafting percentage increase from 15 to 50%, the antibacterial activities against Gram‐positive S. aureus and Gram‐negative E. coli gradually increase from 87 to 95% and from 94 to 99%, respectively. The biocompatibility of these sponges is confirmed through an in vitro cell viability assay. All of the survival rates of the bacterial cells relative to the control (100% of metabolic activity) exceed 90% as the extract ratio of PVF‐g‐PSBMA sponges increase. Thus, the as‐prepared PVF‐g‐PSBMA sponges can be an ideal wound dressing candidate. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47047.

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