Cell Cycle Genes PEDF and CDKN1C in Growing Deer Antlers
Citations Over Time
Abstract
Deer antlers are the only mammalian appendage to display an annual cycle of full regeneration. The growth phase in antler involves the rapid proliferation of several tissues types, including epidermis, dermis, cartilage, bone, blood vessels, and nerves. Antlers thus provide an excellent model to study the developmental regulation of these tissues. We describe here the identification of two genes, pigment epithelium-derived factor (PEDF) and cyclin-dependent kinase inhibitor 1C (CDKN1C), both of which are known to be involved in cell proliferation and differentiation. These genes were identified as the result of screening an expressed sequence tag database derived from a cDNA library enriched for sequences from the growing antler tip. PEDF mRNA was detected in developing skin, cartilage, and bone during endochondral ossification. PEDF mRNA was not detected within endothelial cells that exhibited positive immunoreactivity to a CD146 antibody. CDKN1C mRNA was expressed by only the immature chondrocytes within the precartilage region. These results suggested that PEDF and CDKN1C are important genes involved in cell proliferation and differentiation during antler growth.
Related Papers
- → PEDF: a potential molecular therapeutic target with multiple anti-cancer activities(2006)114 cited
- → Radiocarbon Dating Caribou Antler and Bone : Are They Different?(2003)7 cited
- → Pigment epithelium-derived factor (PEDF) and lipid parameters in patients with end stage renal failure before and after kidney allotrasplantation(2018)1 cited
- → Pigment Epithelium Derived Factor in Ocular Vascular Development, Neovascularization and Function(2023)1 cited
- → The association between plasma concentration of pigment epithelium-derived factor and diabetic retinopathy(2023)