Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations
Arthritis & Rheumatism2005Vol. 52(1), pp. 192–200
Citations Over TimeTop 10% of 2005 papers
Johan Frostegård, Elisabet Svenungsson, Ruihua Wu, Iva Gunnarsson, Ingrid E. Lundberg, Lars Klareskog, Sohvi Hörkkö, Joseph L. Witztum
Abstract
In general, patients with SLE (particularly those with cardiovascular disease) had more oxidized epitopes on LDL compared with controls. Furthermore, aCL in these patients recognized epitopes generated during lipid peroxidation. Thus, "neo" self antigens on lipoproteins, generated during oxidation, are present in SLE and may be of importance for the development of premature cardiovascular disease and possibly also for other autoimmune phenomena observed in SLE.
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