Combination treatment with methotrexate, cyclosporine, and intraarticular betamethasone compared with methotrexate and intraarticular betamethasone in early active rheumatoid arthritis: An investigator‐initiated, multicenter, randomized, double‐blind, parallel‐group, placebo‐controlled study
Arthritis & Rheumatism2006Vol. 54(5), pp. 1401–1409
Citations Over TimeTop 10% of 2006 papers
Merete Lund Hetland, Kristian Stengaard‐Pedersen, Peter Junker, Tine Lottenburger, Torkell Ellingsen, Lis Smedegaard Andersen, Ib Tønder Hansen, Henrik Skjødt, Jens Kristian Pedersen, Ulrik Birk Lauridsen, Anders Jørgen Svendsen, Ulrik Tarp, Jan Pødenphant, G. Hansen, Hanne Lindegaard, Anselmo de Carvalho, Mikkel Østergaard, Kim Hørslev‐Petersen
Abstract
Combined treatment with methotrexate and intraarticular glucocorticoid showed excellent disease control and stopped the progression of erosions in patients with early active RA, who had a poor prognosis. Addition of cyclosporine improved the ACR20 and ACR-N responses, whereas the ACR50 and ACR70 responses, remission rates, and radiographic changes did not differ between the 2 study groups.
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