Risk of serious bacterial infections among rheumatoid arthritis patients exposed to tumor necrosis factor α antagonists
Arthritis & Rheumatism2007Vol. 56(4), pp. 1125–1133
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Jeffrey R. Curtis, Nivedita M. Patkar, Aiyuan Xie, Carolyn Martin, Jeroan J. Allison, Michael S. Saag, Deborah Shatin, Kenneth G. Saag
Abstract
The multivariable-adjusted risk of hospitalization with a physician-confirmed definite bacterial infection was approximately 2-fold higher overall and 4-fold higher in the first 6 months among patients receiving TNFalpha antagonists versus those receiving MTX alone. RA patients were at increased risk of serious infections, irrespective of the method used to define an infectious outcome. Patients and physicians should vigilantly monitor for signs of infection when using TNFalpha antagonists, particularly shortly after treatment initiation.
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