Peptidyl arginine deiminase type 2 (PAD‐2) and PAD‐4 but not PAD‐1, PAD‐3, and PAD‐6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation
Arthritis & Rheumatism2007Vol. 56(11), pp. 3541–3553
Citations Over TimeTop 10% of 2007 papers
Céline Foulquier, Mireille Sebbag, C Clavel, Sabine Chapuy‐Regaud, Roula Al Badine, Marie‐Claire Méchin, Christian Vincent, Rachida Nachat, Michiyuki Yamada, Hidenari Takahara, Michel Simon, Marina Guerrin, Guy Serre
Abstract
PAD-2 and PAD-4 are the only PAD isotypes expressed in the ST of patients with RA and those with other arthritides. Inflammatory cells are a major source, but PAD-4 also comes from hyperplastic synoviocytes. Both isotypes are probably involved in the citrullination of fibrin.
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