Double‐knockout of ADAMTS‐4 and ADAMTS‐5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis
Arthritis & Rheumatism2007Vol. 56(11), pp. 3670–3674
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Manas K. Majumdar, Roger Askew, Scott H. Schelling, Nancy Stedman, Tracey Blanchet, Bei Hopkins, Elizabeth A. Morris, S.S. Glasson
Abstract
Dual deletion of ADAMTS-4 and ADAMTS-5 generated mice that were phenotypically indistinguishable from WT mice. Deletion of ADAMTS-4/5 provided significant protection against proteoglycan degradation ex vivo and decreased the severity of murine OA. These effects in the ADAMTS-4/5-double-knockout mice were comparable with those observed with deletion of ADAMTS-5 alone.
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