Antibodies to citrullinated α‐enolase peptide 1 are specific for rheumatoid arthritis and cross‐react with bacterial enolase
Arthritis & Rheumatism2008Vol. 58(10), pp. 3009–3019
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Karin Lundberg, A. J. Kinloch, Benjamin A. Fisher, Natalia Wegner, Robin Wait, P. Charles, Ted R. Mikuls, Patrick J Venables
Abstract
We have identified an immunodominant epitope in citrullinated alpha-enolase, to which antibodies are specific for RA. Our data on sequence similarity and cross-reactivity with bacterial enolase may indicate a role for bacterial infection, particularly with P gingivalis, in priming autoimmunity in a subset of patients with RA.
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