Induction of an osteoarthritis‐like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice
Arthritis & Rheumatism2008Vol. 58(10), pp. 3132–3144
Citations Over TimeTop 10% of 2008 papers
Qiuqian Wu, Kyung‐Ok Kim, Erik R. Sampson, Di Chen, Hani A. Awad, Todd O'Brien, J. Edward Puzas, Hicham Drissi, Edward M. Schwarz, Regis J. O’Keefe, Michael J. Zuscik, Randy N. Rosier
Abstract
Smurf2 is up-regulated during OA in humans, and Smurf2-transgenic mice spontaneously develop an OA-like phenotype that correlates with decreased TGFbeta signaling and increased pSmad3 degradation. Overall, these results suggest a role of Smurf2 in the pathogenesis of OA.
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