Membrane type 1 matrix metalloproteinase is a crucial promoter of synovial invasion in human rheumatoid arthritis
Arthritis & Rheumatism2009Vol. 60(3), pp. 686–697
Citations Over TimeTop 10% of 2009 papers
Mary-Clare Miller, Hugh B. Manning, Abhilash Jain, Linda Troeberg, Jayesh Dudhia, David W. Essex, Ann Sandison, Motoharu Seiki, Jagdeep Nanchahal, Hideaki Nagase, Yoshifumi Itoh
Abstract
MT1-MMP serves as an essential collagen-degrading proteinase during pannus invasion in human RA. Specific inhibition of MT1-MMP-dependent invasion may represent a novel therapeutic strategy for RA.
Related Papers
- → Transforming growth factor-β1 in rheumatoid synovial membrane and cartilage pannus junction(1991)96 cited
- Substrate choice of membrane-type 1 matrix metalloproteinase is dictated by tissue inhibitor of metalloproteinase-2 levels(2007)
- ヒト糸球体疾患の糸球体におけるmatrix metalloproteinase(MMP)-2、MMP-9、tissue inhibitor of metalloproteinase(TIMP)-1、TIMP-2の発現(2005)
- Recent Developments of Study about The Relationship of Matrix Metalloproteinase,Tissue Inhibitor of Metalloproteinase with Invasion of Meningiomas(2007)