Association of ERAP1, but not IL23R, with ankylosing spondylitis in a Han Chinese population
Arthritis & Rheumatism2009Vol. 60(11), pp. 3263–3268
Citations Over TimeTop 10% of 2009 papers
Stuart I. Davidson, Xin Wu, Yu Liu, Meng Wei, Patrick Danoy, Gethin Thomas, Qing Cai, Linyun Sun, Emma L. Duncan, Niansong Wang, Qing-Hong Yu, Anlong Xu, Yonggui Fu, Matthew A. Brown, Huji Xu
Abstract
Our results demonstrate that genetic polymorphisms in ERAP1 are associated with AS in Han Chinese, suggesting a common pathogenic mechanism for the disease in Chinese and Caucasian populations, and that IL23R is not associated with AS in Chinese, indicating a difference in the mechanism of disease pathogenesis between Chinese and Caucasian populations. This may result from the fact that rs11209026, the nonsynonymous SNP in IL23R, is not polymorphic in Chinese patients, providing further evidence that rs11209026 is the key polymorphism associated with AS (and likely inflammatory bowel disease and psoriasis) in this gene.
Related Papers
- → Gene and pathway-based second-wave analysis of genome-wide association studies(2009)240 cited
- → Lessons and implications from association studies and post-GWAS analyses of cervical cancer(2014)59 cited
- → Genome-wide association studies in aging-related processes such as diabetes mellitus, atherosclerosis and cancer(2007)43 cited
- → A genome-wide association study links small-vessel ischemic stroke to autophagy(2017)19 cited
- → GWAS summary-based pathway analysis correcting for the genetic confounding impact of environmental exposures(2017)4 cited