HLA–DPB1 and DPB2 are genetic loci for systemic sclerosis: A genome‐wide association study in Koreans with replication in North Americans
Arthritis & Rheumatism2009Vol. 60(12), pp. 3807–3814
Citations Over TimeTop 10% of 2009 papers
Xiaodong Zhou, Jong Eun Lee, Frank C. Arnett, Momiao Xiong, Min Young Park, Yeon Kyeong Yoo, Eun‐Soon Shin, John D. Reveille, Maureen D. Mayes, Jinhyun Kim, Ran Song, Ji Yong Choi, Ji Ah Park, Yun Jong Lee, Eun Young Lee, Yeong Wook Song, Eun Bong Lee
Abstract
The results of our genome-wide association study in Korean subjects indicate that the region of HLA-DPB1 and DPB2 contains the loci most susceptible to SSc in a Korean population. The confirmatory studies in US Caucasians indicate that specific SNPs of HLA-DPB1 and/or DPB2 are strongly associated with US Caucasian patients with SSc who are positive for anti-DNA topoisomerase I or anticentromere autoantibodies.
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