Protection against anti–citrullinated protein antibody–positive rheumatoid arthritis is predominantly associated with HLA–DRB1*1301: A meta‐analysis of HLA–DRB1 associations with anti–citrullinated protein antibody–positive and anti–citrullinated protein antibody–negative rheumatoid arthritis in four European populations
Arthritis & Rheumatism2010Vol. 62(5), pp. 1236–1245
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Diane van der Woude, Benedicte A. Lie, Emeli Lundström, Alejandro Balsa, Anouk L. Feitsma, Jeanine J. Houwing‐Duistermaat, Willem Verduijn, Gry B. N. Nordang, Lars Alfredsson, Lars Klareskog, Dora Pascual‐Salcedo, Miguel Á. González‐Gay, Miguel Ángel López‐Nevot, F Casanova Valero, Bart O. Roep, T. Huizinga, Tore K. Kvien, Javier Martı́n, Leonid Padyukov, René R. P. de Vries, René E. M. Toes
Abstract
Our data do not support any of the classifications of protective alleles and indicate that protection against ACPA-positive RA is predominantly associated with HLA-DRB1*1301.
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