Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis
Arthritis & Rheumatism2010Vol. 62(7), pp. 1955–1966
Citations Over TimeTop 10% of 2010 papers
Jennifer M Milner, Amit Patel, Rose K. Davidson, T.E. Swingler, Antoine Désilets, David A. Young, Elizabeth B. Kelso, Simon Donell, Tim E. Cawston, Ian M. Clark, William R. Ferrell, Robin Plevin, John C. Lockhart, Richard Leduc, Andrew D. Rowan
Abstract
Elevated matriptase expression in OA and the ability of matriptase to activate selective proMMPs as well as induce collagenase expression make this serine proteinase a key initiator and inducer of cartilage destruction in OA. We propose that the indirect effects of matriptase are mediated by PAR-2, and a more detailed understanding of these mechanisms may highlight important new therapeutic targets for OA treatment.
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