Altered expression of microRNA‐203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation
Arthritis & Rheumatism2010Vol. 63(2), pp. 373–381
Citations Over TimeTop 1% of 2010 papers
Joanna Stańczyk, Caroline Ospelt, Emmanuel Karouzakis, Andrew Filer, Karim Raza, Christoph Kolling, Renate Gay, Christopher D. Buckley, Paul P. Tak, Steffen Gay, Diego Kyburz
Abstract
The current results demonstrate methylation-dependent regulation of miR-203 expression in RASFs. Importantly, they also show that elevated levels of miR-203 lead to increased secretion of MMP-1 and IL-6 via the NF-κB pathway and thereby contribute to the activated phenotype of synovial fibroblasts in RA.
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