A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis
Arthritis & Rheumatism2010Vol. 63(3), pp. 819–829
Citations Over TimeTop 10% of 2010 papers
Elizabeth S. Fernandes, Fiona A. Russell, Domenico Spina, Jason J. McDougall, Rabea Graepel, Clive Gentry, Amelia A. Staniland, David M. Mountford, Julie Keeble, Marzia Malcangio, Stuart Bevan, Susan D. Brain
Abstract
Evidence suggests that endogenous activation of peripheral TRPA1 receptors plays a critical role in the development of TNFα-induced mechanical hyperalgesia and in sustaining the mechanical hyperalgesia observed after intraaarticular injection of CFA. These results suggest that blockade of TRPA1 receptors may be beneficial in reducing the chronic pain associated with arthritis.
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