TSG‐6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with osteoprotegerin
Arthritis & Rheumatism2010Vol. 63(4), pp. 1034–1043
Citations Over TimeTop 16% of 2010 papers
David J. Mahoney, Catherine Swales, Nicholas A. Athanasou, Stefano Bombardieri, Costantino Pitzalis, K Kliskey, Mohammed Sharif, Anthony J. Day, Caroline M. Milner, Afsie Sabokbar
Abstract
In the presence of inflammatory cytokines, osteoclasts produced TSG-6 at concentrations that are sufficient to inhibit lacunar resorption. This may represent an autocrine mechanism to limit the degree of bone erosion during joint inflammation.
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