Time‐series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis
Arthritis & Rheumatism2012Vol. 64(10), pp. 3256–3266
Citations Over TimeTop 10% of 2012 papers
B. Poulet, Veronica Ulici, Timothy Stone, Matthew J. Pead, Valentina Gburcik, E Constantinou, Donald B. Palmer, Frank Beier, James A. Timmons, Andrew A. Pitsillides
Abstract
This study is the first to show that AC chondrocytes share a high-abundance gene-expression program with skeletal muscle. We show that failure to switch this program off, as well as the restoration of this program, is associated with inappropriate expression of NF-κB signaling pathways, skeletal muscle-related genes, and induction and/or progression of OA.
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