Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury
Arthritis & Rheumatism2012Vol. 65(3), pp. 721–731
Citations Over TimeTop 10% of 2012 papers
Martine P. Roudier, Xiaodong Li, Qing‐Tian Niu, Efrain Pacheco, James K. Pretorius, Kevin C. Graham, Bo‐Rin P. Yoon, Jianhua Gong, Kelly Warmington, Hua Zhu Ke, Roy A. Black, Joanne T. Hulme, Philip Babij
Abstract
Genetic absence of sclerostin does not alter the normal development of age-dependent OA in mice, and pharmacologic inhibition of sclerostin with Scl-Ab has no impact on articular cartilage remodeling in rats with posttraumatic OA.
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