Disrupted Brain Circuitry for Pain‐Related Reward/Punishment in Fibromyalgia
Arthritis & Rheumatology2013Vol. 66(1), pp. 203–212
Citations Over TimeTop 10% of 2013 papers
Marco L. Loggia, Chantal Berna, Jieun Kim, Christine Cahalan, Randy L. Gollub, Ajay D. Wasan, Richard E. Harris, Robert R. Edwards, Vitaly Napadow
Abstract
FM patients exhibit disrupted brain responses to reward/punishment. The ventral tegmental area is a source of reward-linked dopaminergic/γ-aminobutyric acid-releasing (GABAergic) neurotransmission in the brain, and our observations are compatible with reports of altered dopaminergic/GABAergic neurotransmission in FM. Reduced reward/punishment signaling in FM may be related to the augmented central processing of pain and reduced efficacy of opioid treatments in these patients.
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