Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid
Arthritis & Rheumatology2015Vol. 67(12), pp. 3135–3145
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Júlia Spengler, B. Lugonja, A. Jimmy Ytterberg, Roman A. Zubarev, Andrew J. Creese, Mark Pearson, Melissa M. Grant, Michael R. Milward, Karin Lundberg, Christopher D. Buckley, Andrew Filer, Karim Raza, Paul R. Cooper, Iain Chapple, Dagmar Scheel‐Toellner
Abstract
Release of active PAD isoforms into the SF by neutrophil cell death is a plausible explanation for the generation of extracellular autoantigens in RA.
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