Comparing Presenting Clinical Features in 48 Children With Microscopic Polyangiitis to 183 Children Who Have Granulomatosis With Polyangiitis (Wegener's): An ARChiVe Cohort Study
Arthritis & Rheumatology2016Vol. 68(10), pp. 2514–2526
Citations Over TimeTop 10% of 2016 papers
David A. Cabral, Debra Canter, Eyal Muscal, Kabita Nanda, Dawn M. Wahezi, Steven J. Spalding, Marinka Twilt, Susanne M. Benseler, Sarah Campillo, Sirirat Charuvanij, Paul Dancey, B. Anne Eberhard, Melissa E. Elder, Aimee O. Hersh, Gloria C. Higgins, Adam M. Huber, Raju Khubchandani, Susan Kim, Marisa S. Klein‐Gitelman, Mikhail M. Kostik, Erica Lawson, Tzielan Lee, Joanna M. Lubieniecka, Deborah McCurdy, Lakshmi N. Moorthy, Kimberly Morishita, Susan Nielsen, Kathleen M. O’Neil, Andreas Reiff, Goran Ristic, Angela Byun Robinson, Angelyne Sarmiento, Susan Shenoi, M. Toth, Heather A. Van Mater, Linda Wagner‐Weiner, Jennifer E. Weiss, Andrew J. White, Rae S. M. Yeung, the ARChiVe Investigators Network within the PedVas Initiative
Abstract
Younger age at disease onset and, perhaps, both gastrointestinal manifestations and more severe kidney disease seem to characterize the clinical profile in children with MPA compared to those with GPA. Delay in diagnosis suggests that recognition of these systemic vasculitides is suboptimal. Compared with adults, initial treatment regimens in children were comparable, but the complete reversal of female-to-male disease prevalence ratios is a provocative finding.
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