Interleukin‐23–Dependent γ/δ T Cells Produce Interleukin‐17 and Accumulate in the Enthesis, Aortic Valve, and Ciliary Body in Mice
Arthritis & Rheumatology2016Vol. 68(10), pp. 2476–2486
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Annika Reinhardt, Tetyana Yevsa, Tim Worbs, Stefan Lienenklaus, Inga Sandrock, Linda Oberdörfer, Thomas Korn, Siegfried Weiß, Reinhold Förster, Immo Prinz
Abstract
Entheseal γ/δ T cells are derived from fetal thymus and are maintained as self-renewing tissue-resident cells. As main IL-17A producers within tissues exposed to mechanical stress including enthesis, γ/δ T cells are key players in the pathogenesis of IL-23-induced local inflammation.
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