Modulation of Hedgehog Signaling by Kappa Opioids to Attenuate Osteoarthritis
Arthritis & Rheumatology2020Vol. 72(8), pp. 1278–1288
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Alexander E. Weber, Omid Jalali, Sean Limfat, Ruzanna Shkhyan, Robert A. van der Horst, Siyoung Lee, Yucheng Lin, Liangliang Li, Erik N. Mayer, Liming Wang, Nancy Q. Liu, Frank A. Petrigliano, Jay R. Lieberman, Denis Evseenko
Abstract
The results of this study define a novel mechanism for the role of KOR in articular cartilage homeostasis and disease, providing a potential unifying mechanistic basis for the overlap in disease processes and features involving opioid and HH signaling. Moreover, this study identifies a potential novel therapeutic strategy in which KOR modulation can improve outcomes in patients with OA.
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