Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor–Induced Caspase 3/Gasdermin E–Mediated Pyroptosis
Arthritis & Rheumatology2021Vol. 74(3), pp. 427–440
Citations Over TimeTop 10% of 2021 papers
Zeqing Zhai, Fangyuan Yang, Wenchao Xu, Jiaochan Han, Guihu Luo, Yehao Li, Jian Zhuang, Hong-Yu Jie, Xing Li, Xingliang Shi, Xinai Han, Xiaoqing Luo, Rui Song, Yonghong Chen, Jianheng Liang, Shufan Wu, Yi He, Erwei Sun
Abstract
These results support the notion of a pathogenic role of GSDME in RA and provide an alternative mechanism for RA pathogenesis involving TNF, which activates GSDME-mediated pyroptosis of monocytes and macrophages in RA. In addition, targeting GSDME might be a potential therapeutic approach for RA.
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