De Novo PACSIN1 Gene Variant Found in Childhood Lupus and a Role for PACSIN1/TRAF4 Complex in Toll‐like Receptor 7 Activation
Arthritis & Rheumatology2023Vol. 75(6), pp. 1058–1071
Citations Over TimeTop 10% of 2023 papers
Chengmei Xie, Haibo Zhou, Vicki Athanasopoulos, Qian Shen, Yaoyuan Zhang, Xiangpeng Meng, Gaétan Burgio, Todor Arsov, Adrian Lungu, Pingjing Zhang, Yuting Qin, Jiangyang Ma, Xiaoqian Wu, Xiaoyue Jiang, Huihua Ding, Yao Meng, Nan Shen, Yuke He, Carola G. Vinuesa
Abstract
PACSIN1 Q59K increases IFNβ activity through the impairment of TRAF4-mediated inhibition of TLR-7 signaling, possibly contributing to SLE risk.
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