HIV protease inhibitors: garlic supplements and first‐pass intestinal metabolism impact on the therapeutic efficacy
Biopharmaceutics & Drug Disposition2010Vol. 31(8-9), pp. 495–505
Citations Over TimeTop 10% of 2010 papers
Abstract
The fractions of tested anti-HIV drugs absorbed could decrease significantly during self-medication with garlic supplements or ritonavir dose adjustments. Due to distinct saquinavir and darunavir preferences for binding sites on efflux transporters, the presence of other compounds (garlic phytochemicals, ritonavir), capable of influencing intestinal transporter-enzyme interplay, might lead to pharmacokinetic interactions observed in clinical studies and case reports with anti-HIV drugs.
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