Cleft lip and palate results from Hedgehog signaling antagonism in the mouse: Phenotypic characterization and clinical implications
Birth Defects Research Part A Clinical and Molecular Teratology2010Vol. 88(4), pp. 232–240
Citations Over TimeTop 13% of 2010 papers
Robert J. Lipinski, Chihwa Song, Kathleen K. Sulik, Joshua L. Everson, Jerry J. Gipp, Yan Dong, Wade Bushman, Ian J. Rowland
Abstract
The results of this study suggest that interference with Hh signaling should be considered in the CLP differential and highlight the occurrence of CNS defects that are expected to be present in a cohort of patients having CLP. This work also illustrates the utility of fetal MRI-based analyses and establishes a novel mouse model for teratogen-induced CLP.
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