A Comparison of ToxCast Test Results with In Vivo and Other In Vitro Endpoints for Neuro, Endocrine, and Developmental Toxicities: A Case Study Using Endosulfan and Methidathion
Birth Defects Research Part B Developmental and Reproductive Toxicology2015Vol. 104(2), pp. 71–89
Citations Over TimeTop 10% of 2015 papers
Marilyn Silva, Nathalie Pham, Claire E. Lewis, Shoba Iyer, Eric S. C. Kwok, Gina Solomon, Lauren Zeise
Abstract
ToxCast's predictions showed concordance on some endpoints and nonconcordance, consisting mainly of false inactives, in several critical endpoints, likely due to a lack of metabolic activation and limitations in assay design. Zebrafish assays were good predictors of developmental toxicity and neurotoxicity for endosulfan.
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