Effects of continuous and intermittent exposure to RF fields with a wide range of SARs on cell growth, survival, and cell cycle distribution

Citations Over TimeTop 10% of 2006 papers

Abstract

To examine the biological effects of radio frequency (RF) electromagnetic fields in vitro, we have examined the fundamental cellular responses, such as cell growth, survival, and cell cycle distribution, following exposure to a wide range of specific absorption rates (SAR). Furthermore, we compared the effects of continuous and intermittent exposure at high SARs. An RF electromagnetic field exposure unit operating at a frequency of 2.45 GHz was used to expose cells to SARs from 0.05 to 1500 W/kg. When cells were exposed to a continuous RF field at SARs from 0.05 to 100 W/kg for 2 h, cellular growth rate, survival, and cell cycle distribution were not affected. At 200 W/kg, the cell growth rate was suppressed and cell survival decreased. When the cells were exposed to an intermittent RF field at 300 W/kg(pk), 900 W/kg(pk) and 1500 W/kg(pk) (100 W/kg(mean)), no significant differences were observed between these conditions and intermittent wave exposure at 100 W/kg. When cells were exposed to a SAR of 50 W/kg for 2 h, the temperature of the medium around cells rose to 39.1 degrees C, 100 W/kg exposure increased the temperature to 41.0 degrees C, and 200 W/kg exposure increased the temperature to 44.1 degrees C. Exposure to RF radiation results in heating of the medium, and the thermal effect depends on the mean SAR. Hence, these results suggest that the proliferation disorder is caused by the thermal effect.

Related Papers

• → Growth inhibition of Staphylococcus aureus induced by low‐frequency electric and electromagnetic fields(2009)46 cited
• → A numerical and experimental comparison of human head phantoms for compliance testing of mobile telephone equipment(2005)50 cited
• → Body Feature Intercomparison of Specific Absorption Rate Induced by High-Power, Portable, and Broadband Electromagnetic Sources [Bioelectromagnetics](2023)3 cited
• → Near‐Field Exposure in FM Frequencies: New Methodology and Estimation Formulas(2022)2 cited
• → Setup and dosimetry for exposing anaesthetised pigs in vivo to 900 MHz GSM mobile phone fields(2008)9 cited